CLINICAL EFFICACY OF ENTEROSORPTION IN TREATMENT OF MICROBIAL-INFLAMMATORY AND IMMUNOCOMPLEX KIDNEY DISEASES IN CHILDREN
I.V. Bagdasarova, Institute of Nephrology AMS of Ukraine, O.I. Osadchaya, А.М. Boyarskaya, Institute of Hematology and Transfusiology AMS of Ukraine, B.S. Sheyman, N.А. Voloshina, L.I. Medved Institute of Ecohygiene and Toxicology, the Ministry of Health of Ukraine.
The use of enterosorption with Enterosgel medication in combination therapy of children with acute pyelonephritis reduces the toxic load on the neutrophilic granulocytes and contributes to the preservation of functional activity of the given cells at subcompensated level, reducing the risk of generalization of infection and the development of associated complications.
The use of Enterosgel medication in combination therapy of children with acute glomerulonephritis promotes preservation of the functional activity of monocytes and optimization of their participation in the mechanisms of antigen presentation to immune cells, which reduces the risk of autoimmune complications.
ENTEROSORBENT ENTEROSGEL IN CLINICAL PRACTICE, 2016
ln order to assess the characteristics of the medical device ENTEROSGEL, establish the method of its use and the safety for users, this report was drawn up in the form of a critical evaluation of the relevant
published clinical studies conducted with ENTEROSGEL and with other at least partially comparable
medical devices already placed on the European market.
MODERN ENTEROSORPTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT PREDIALYSIS STAGE, 2016
M.S. Barylko, P.V. Seliverstov, V.G. Radchenko
Conclusions. Enterosgel has positive effect on the clinical picture in patients with CRF at the predialysis stage due to its sorption action that helps reduce the endogenous intoxication and improve renal function; upon its use quality of life improves together with psycho-emotional states; Enterosgel has good tolerability, it is safe, improves functional state of the kidneys and can be recommended in the complex therapy of patients with CRF at predialysis stage, in an amount of a single dose 3 times a day 60 minutes before a meal for 4 weeks.
Enterosorbents are one of the highly successful, safe and available prevention , allowing to essentially slow down progression of CRF, postpone beginning of dialysis, reduce the risk of complications and the cost of their treatment, as well as help incurable patients to which active therapy is counterindicated.
ABOUT EXPERIMENTAL PRECLINICAL SAFETY STUDYING OF THE MEDICINAL FORM OF A PREPARATION «ENTEROSGEL®,PASTE FOR INTAKE (SWEET)» GIVEN «TNK SILMA LTD.» (MOSCOW), 2010
THE STUDY DRUG SAFETY OF "ENTEROSGEL®, PASTA FOR INTAKE (SWEET)" ALLOWS TO RECOMMEND ITS SUBMISSION TO THE TO THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION AS LOW-TOXICITY DRUG AS THE PROCEDURE FOR EXPANDING INDICATIONS AND CHANGES IN INSTRUCTION FOR USE.
COLLECTION OF RESEARCH PAPERS. ENTEROSGEL RESEARCHES, 2015
Dzyublik I, Shunko Em, Barbova A. Clinical efficacy of Enterosgel in treatment of rotovirus infections in newborns
Gorodetsky, Tebechevsky F Clinical efficacy of Enterosgel in treatment of patients with hepatitis A
Tkachenko E., Avalueva E. The Clinical Efficacy and safety of Enterosgel in the treatment of diarrhoea-dominant irritable bowel syndrome.
Tkachenko E., Avalueva E. The Clinical Efficacy and safety of Enterosgel in the treatment of Helicobacter Pylori – associated chronic gastroduodentis
Astahov V., Gusev V. The Clinical Efficacy and safety of Enterosgel in complex prevention of fetoplacental dysfunction in pregnant women with earlier syphilis
Usenko D., Gorelov A. The Clinical Efficacy of Enterosgel, in treatment of intestinal infections in chidren with atopic dermatitis.
Radchenko V., Seliverstov P. The Clinical Efficacy and safety of Enterosgel in treatment of predialysis Cronic Renal Falure (CRF) patients.
Nakhashova V. The Clinical Efficacy of Enterosgel in treatment of patients with Chronic Pancreatitis
Karlyichuk A., Kulachek F. The Clinical Efficacy of Enterosgel in complex treatment and prophylaxis of post-operative intraperitoneal in complication of acute cholecystitis
Moroz L., Paliy M. Use of enterosorbent Enterosgel in complex therapy of acute viral hepatitis B with concomitant intestinal dysbiosis
Sokolov E., Majev I. Clinical efficacy of Enterosgel in patients with digestive system-relative pathology.
Paliy I., Tchernobroviy V. Clinical efficacy of Enterosgel in complex treatment of intestinal dysbiosis
Yurchenko A., Nikolaev V. Clinical efficacy of Enterosgel in treatment of intoxication and diarrhoea in patients with AIDS during antiretroviral therapy.
COLLECTION OF RESEARCH PAPERS. GASTROENTEROLOGY: NEW APPROACHES, 2014
Paliy I.G., Reznichenko I.G. A Modern View on the Issue of Enterosorption: Choosing the O ptimal Drug
Tkach S.M. Effectiveness of Enterosorbent Enterosgel in Combined Anti-Helicobacter Therapy for Patients with Peptic Ulcer Disease
Osadchaya O.I., Boyarskaya A.M. Clinical Effectiveness of Enterosorption in Reduction of Endogenous Intoxication Syndrome in Patients with Nonspecific Ulcerative Colitis
Osadchaya O.I., Shmatova E.A., Boyarskaya A.M. Role of Detoxification Therapy in Maintaining Toxin-binding Capacity of Peripheral Blood Albumin in Patients with Alcoholic Liver Disease
Zaytseva N.V., Aminova A.I., Akatova A.A., Minchenko Ye. Yu. Peculiarities of Eradication Therapy for Chronic H. pylori-associated Gastroduodenitis in Children Living in Ecologically Unfavorable Conditions
Fedorova O.V., Fedulova E.N., Tutina O.A., Korkotashvili L.V. Endogenous Intoxication in Inflammatory Bowel Disease in Children: Substantiation of Detoxification Therapy Using Enterosorption Method
Boyarskaya A.M., Osadchaya O.I., Zhernov A.A., Kovalenko O.N.Use of Enterosorbent Enterosgel in Combination Treatment of Intestinal Dysbiosis in Children with Burn Disease
Enterosgel® in Gastroenterology: Posology and Method of Administration
Dosage and Administration of Enterosgel® for the Treatment of Acute Diarrhea
COLLECTION OF RESEARCH PAPERS. ALLERGOLOGY, IMMUNOLOGY, DERMATOLOGY: NEW APPROACHES, 2013
J. Bystron: “...the basis of allergy management consists first and foremost of the identification of the causal allergen and the effort aimed at its elimination...”
Nagornaya N.V., Dubovaya A.V. The Detoxifying Potential and Clinical Effectiveness of the Enterosorbent Enterosgel in the Combination Therapy of Various Diseases in Children and Adults
Shamov B.A., Malanicheva T.G. Correction of Systemic Endotoxemia in Children with Atopic Dermatitis
Melnykov O.F., Zabrodska L.V., Tymchenko M.D., Sydorenko T.V., Naumova O.A. A Clinical and Immuno-Allergological Study of the Efficacy of Enterosgel in Food Allergy
Malanicheva T.G., Khaertdinova L.A. Enterosorption in the Treatment of Pediatric Atopic Dermatitis Complicated by Fungal Infection
Baranov A.A, Geppe N.A, Karpushkina A.V. The Efficacy of Enterosgel in the Treatment of Children with Bronchial Asthma and Atopic Dermatitis
J. Bystron. Application of Enterosorption Method with Organosilicon Enterosorbent Enterosgel in the Integrated Treatment of Allergic Diseases
Zaytseva N.V, Aminova A.I., Ustinova O.Yu., Akatova A.A., Luzhetskiy K.P. Asthma Prevention in Children with Recurrent Wheezing Bronchitis Who Have Elevated Levels of Heavy Metals and Aldehydes in the Body
Basieva O.Z., Basiev Z.G. Enterosgel in the Combination Treatment of Atopic Bronchial Asthma
Chorna O.O, Binda T.P. On the Issue of the Treatment of Children with Allergic Diseases
Enterosgel® in Allergology and Dermatology: Posology and Method of Administration
SINGLE-CENTER, PROSPECTIVE, OPEN, CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF ENTEROSGEL® IN NEPHROLOGY, ADMINISTERED TO PREDIALYSIS CRF PATIENTS, 2014
Radchenko V.G., Seliverstov P.V.
Report parameters: the report is outlined on 34 pages, contains 6 tables, 1 figure, 1 appendix and 17 literary sources.
List of key words: chronic renal diseases, sorbent, Enterosgel, dialysis.
In the following research feasibility of sorbent Enterosgel® has been studied in predialysis patients with CRF. The work presented has scientifically proven that use of Enterosgel® is effective and safe.
It has been established that the incidence of renal diseases in children in the regions of cement industry is very high, especially regarding dysmetabolic nephropathy, unlike the control region, which shows the significant role of environmental factors in the development of renal damage. The conducted studies of Kudin M.V. (2012)  have shown that in children and adults living in the area and having no renal diseases cadmium - toxic element, hazard class 1 - accumulates in kidney tissue, which justifies the use of enterosorbent Enterosgel in persons living in the region as a prophylactic purpose.
Enterosgel not only prevents accumulation of toxic substances into the body by their intestinal adsorption, but also contributes to the removal of heavy metals from the urinary system. Inclusion of Enterosgel in the therapy of children with renal diseases living in the region of cement industry leads to the increased urinary excretion of cadmium, chromium, antimony, and arsenic and improvement of urinary symptoms and, above all, reduction of proteinuria, reflecting improved reabsorption function of the epithelium of proximal tubules.
No undesirable effects have been registered in children receiving Enterosgel.
In the recent decades, a steady increase in the number of patients with end-stage chronical kidney disease (CKD) has been observed all over the world. This makes the problem of CKD treatment one of the central in modern nephrology. Considerable progress of renal replacement therapy (RRT), scientific and technical achievements in the field of hemodialysis, widespread introduction of clinic peritoneal dialysis and kidney transplantation have created real conditions for the successful solution of this problem. Bad life prognosis and the inevitable disablement have gone, as well as necessity of absolute avoidance from active social and professional activity [7,11]. At the same time it has become clear that it is important not only to extend life, but also to ensure its high quality.
ON ESTABLISHMENT OF LARGE-SCALE PRODUCTION AND HEALTHCARE IMPLEMENTATION OF NOVEL HIGHLY EFFECTIVE POLYORGANOSILOXANE-BASED ADSORBENT DRUGS WITH DETOXIFYING EFFECT, 1994
Bezlyuda N.P., Baranyuk A.P.
Novel intestinal and topical adsorbent drugs with detoxifying effect (studies were conducted in 1980-1990 by order of Main Military Clinical Hospital of the Ministry of Defense of Ukraine) were widely evaluated in military medical facilities. The Military Hospital of Kyiv (nowadays the Main Military Clinical Hospital of the Ministry of Defense of Ukraine) participated in the medical and biological evaluation of novel drugs from the beginning of their development (V.N. Fadeev, F.G. Novikov, N.P. Bezlyuda).