Enterosgel® for Allergy and Immunology, Dermatology

This is a selected article or short review based on some of clinical studies. For more information visit our Clinical study database.

Allergy

AllergyAllergies and atopic illnesses are related to gastric disturbances. Food allergies are caused by pathogenesis regarding absorption of certain foods in gastrointestinal tract.

Enterosgel® selectively collects the unfriendly particles and toxic substances including Gram-negative bacteria from the surface of mucous membranes in the gut lumen. The product implies an important property to bind endotoxins while passing through intestinal tract.

It helps to prevent development of viruses and allergic issues that excessive endotoxin level results in. Enterosgel® reduces the pressure on the gut mucous membrane and fastens its restoration.

Allergic reactions occur in case of impaired antigen being absorbed in the organism. The interrupted intestinal penetrability and immunoglobulin reduction lead to pathological processes. Endotoxins when accumulated in the body cause different diseases and act as pathogenesis of allergies. Enterosgel®   acts as a smooth gentle sponge on the sensitive gut lumen surface and removes the pathogenic substances safely without causing any irritation.

Enterosgel for Allergy

Enterosgel® is capable of absorbing the endotoxins from the body that gives positive effect on regenerating the intestinal epithelium (Figure 1) [1g]*. Healthy intestinal epithelium helps maintain the natural microflora and support the immune system. As a result of normalized micfoflora the immune system boosts and natural body defence mechanisms get back to physical norm.

The relief results in normalization of blood endotoxin proportion [3g] and dissension of allergic symptoms (Figure 2) [2a]. Healthy intestinal permeability control system allows the nutrients and minerals absorb into the body and facilitate cell metabolism and regeneration.

Treatment of 40 children suffering from asthma.

40 young children with a diagnosis of polyvalent sensitization to food and domestic allergens were administered Enterosgel® therapy. 22 children out of 40 had symptoms  or suffered from atopic dermatitis and concomitant disease. All the patients had gastric issues. The positive dynamics regarding inner and outer condition started to appear by the 3rd day of the course: the rash and breathing issues (Figure 5) [5a] reduced significantly.

On the 5th day of the treatment half of the patients had significant positive improvements. Skin irritation, redness and itchiness regressed. After 10 days of treatment 85% of the patients got stable relief from skin manifestations, and after 2 weeks breathing issues predominantly eliminated.

Eighty-eight patients with recurrent urticaria and angioneurotic oedema, aged from 24 to 67 years, disease duration from 2 to 11 years.

Enterosgel treatmentOn the 3rd day of Enterosgel® treatment irritation and itchiness intensity decreased. By the 5th day patients had stable relief from the symptoms of edema, urticaria and manifestations. The itchiness issue still remained and caused irritation and discomfort.

The urticarial symptoms completely eliminated after 10-12 days of treatment.  After the first week the first stable improvements started to happen. The clinical symptoms fully regressed by the 20-21st day (Figure 6) [6a].

The earliest positive results of treatment show from 4th or 5th day of treatment. It takes 5 or 6 days for the human gut surface epithelium to regenerate. The clinical results can be seen After 4 or 5 days of therapy [5a, 6a].

The similar effect of Enterosgel® is seen when treating atopic illnesses or pseudo-allergic syndromes. The positive dynamics and results are seen after 3-5 days of treatment.

Allergy

The reason is the capability of Enterosgel® to absorb endotoxins and maintain the natural barrier of the organism. The normal endotoxins balance deactivates truly- and pseudo-allergic reactions. The condition of skin manifestations and irritation diminishes along with the course.

Skin and respiratory manifestations are alleviated by the 3rd or 4th day of an Enterosgel® -including treatment regimen.

The evaluation included 99 children from 4 months to 14 years old. One third of the children suffered from allergy with reagin-mediated mechanism, including rush, itchiness and symptoms of atopic disease.  The symptoms were caused by pseudo- or pure allergic reaction.

After 3 days of the Enterosgel® therapy 75% of patients had improvements and relief from angioneurotic edema. Complex gastric and dyspeptic issues regressed, patients reported normal stool and no more qualmishness or nausea.

Enterosgel therapy

Children that weren’t administered Enterosgel® therapy had comparatively less improvement in the same time frame. 22% of patients experienced relief, but majority still suffered from intestinal issues (up to 8 days), breathing problems and skin manifestations (Figure 7) [7a].

Enterosgel® -treated children with atopic dermatitis

Enterosgel® treatment along with medical therapy shows more successful and fast improvement comparing to anti-allergy and antimicrobial therapy alone. After a 3-weeks Enterosgel® course medical tests for atopic dermatitis patients with secondary infection complications showed a decrease of total IgE concentration.

The absorption of food allergens via gastric mucous membrane significantly decreased due to intestinal improvements and repaired tissue and resulted in IgE reduction (Figure 8) [3a].

Enterosgel® therapy is accompanied by decreased sensitization to food allergens

After 3 month of Enterosgel® treatment general sensitivity to food allergens of children with atopic dermatitis with secondary infection complication dropped by half or even 3 times (p < 0.05) (Figure9) [3a].

atopic dermatitis

Sensitivity to cow milk protein and casein shifted to a low level (class 2) from the high (class 4**).
Egg white protein sensitivity went down from a medium (class 3) to a significanlly low class (class 1).
Sensitization dynamics without Enterosgel® treatment: 1.3- to 1.5-fold (p<0.05).
Comparatively: cow milk protein and casein shifted from a high (class 4) to a medium level (class 3)..
Egg white protein went down from a medium (class 3) to a low level (class 1).

**Notes:

  • Class 1 – significantly low level of specific IgE;
  • Class 2 – low level of specific IgE;
  • Class 3 – medium level of specific IgE;
  • Class 4 – high level of specific IgE;
  • Class 5 – very high level of specific IgE.

 

image8Enterosgel® prolongs relief in children with atopic dermatitis

One and a half year medical research showed that Enterosgel® -treated patients experience longer remission comparing to Enterosgel® -free group (increased only 1.8-fold). For Enterosgel® -administered children exasperations percentage went down from 4 to 1.2 and experienced significantly less itching, redness, irritation on skin or pruritus. In case of a relapse – it took shorter time to recover and milder symptoms occurred.

The prolonged remission and long-term overall improvement showed on the 14th day of a 2-3 weeks course. Sensitization to particular food ingredients dropped down along with the level of serum total IgE and allergen-specific IgE to food allergens (Figure 10) [3a].


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