S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, V. V. Klimontov, L. N. Rachkovskaya, V. I. Konenkov, and E. L. Zavyalov

Non-alcoholic fatty liver disease is one of the most common complications of obesity and type 2 diabetes mellitus (DM2). The structural trace of metabolic changes in the liver during the development of obesity and DM2 is largely determined by the status of sinusoidal cells involved in the formation of the blood — lymph barrier, including epithelial, Kupffer, Ito, and Pit cells [1]. Endothelial cells of hepatic sinusoids express the lymphatic vessel endothelial hyaluronan receptor marker LYVE-1 [10]. The expression of LYVE-1 in the liver in DM2 and the relationship between LYVE-1 expression and structural and functional changes in the hepatic vessels are not been studied.

I.G. Paliy, MD, Professor, Department of outpatient therapy and family medicine, National Pirogov Memorial Medical University, Vinnytsya

Thus, the high efficiency of enterosorbent Enterosgel, its selective sorption action, simplicity and safety, and the possibility of a combination with other medications allow the medical officer to optimize the therapeutic tactics in various diseases of the liver, to achieve high efficiency and reduce time of treatment and rehabilitation of patients.

Koval M.I., Pokotylo O.S.

The results of the influence of enterosorbent “Enterosgel” on the LPO and activities of antioxidant protection enzymes in the one, six-, and twelve-month white rats are given. The study was performed on the model of experimental paracetamol damage of the liver of white rats. It is established that the enterosorbent Enterosgel has antioxidant properties, which were manifested in the decrease of plasma levels of diene conjugate (DC) and malonic dialdehyde (MDA), as well as in the recovery of activities of SOD and catalase in the blood plasma of experimental animals, especially, one- and twelve-month ones.

Key words: paracetamol, hepatitis, rats, lipid peroxidation.