EFFICIENCY OF ENTEROSGEL IN CORRECTION OF SYSTEMIC ENDOTOXEMIA IN CHILDREN WITH ATOPIC DERMATITIS, 2016
T.G. Malanicheva, B.A. Shamov
Endotoxin aggression is developed with the expressed release of endotoxin (ET) in the bloodstream on the background of insufficient activity of excretory systems and is qualified as a universal mechanism involved in the pathogenesis of many infectious and non-infectious diseases . Systemic endotoxemia can develop as a result of both inactive intestinal microbiota, constant permeability disorders of the intestinal mucous membranes, and pancreatic insufficiency, biliary duct insufficiency, depression of liver barrier function or reduced portal blood flow, etc . ET presence affects immunocompetent blood cells and is one of the considerable stimulation factors of the immune system. Under physiological conditions, anti-endotoxin antibodies are released in response to ET presence . In pathological endotoxemia a decline of adaptive capacity and body resistance takes place [4, 5]. It is also known that endotoxemia causes cellular hypoxia, metabolic disorders, activation of sympathetic nervous system, complement system, resulting in lysis of leukocytes and platelet aggregation with the release of biologically active substances – kinins, histamine, serotonin, causing “mediator chaos.”
All of the above has allowed us to make an assumption about the importance of systemic endotoxemia and endotoxin aggression in atopic dermatitis (AD) in children.
Objective: to define level of systemic endotoxemia in children with AD and evaluate drug Enterosgel (polymethylsiloxane polyhydrate) in complex therapy of the pathology.
THE DETOXIFYING POTENTIAL AND CLINICAL EFFECTIVENESS OF THE ENTEROSORBENT ENTEROSGEL IN THE COMBINATION THERAPY OF VARIOUS DISEASES IN CHILDREN AND ADULTS, 2010
Nagornaya N.V., Dubovaya А.V.
The article describes different types of intoxication, presents a method of intracorporeal detoxification, and includes a classification of gastrointestinal adsorbents (enterosorbents). It summarizes the experience that has been gained with the intestinal adsorbent Enterosgel in the combination therapy of children and adults suffering from allergic diseases, gastrointestinal disorders, burn disease, chronic pyelonephritis, and recurrent non-specific vaginitis.