Using Enterosgel

Using Enterosgel in Allergology, Immunology, Dermatology, Gastroenterology,  Paediatrics, Toxicology, Oncology, Infectious diseases,  Nephrology and Gynaecology.

Collection of Research Papers, 2013

Collection of Research Papers 2014

Collection of Research Papers 2015

Enterosgel Clinical Studies database

Enterosgel has a porous structure silica-ethnic matrix (nanosponge), a hydrophobic nature, which is characterized by the sorption effect in relation only to medium weight toxic metabolites litam. The sorption process by Enterosgel follows two mechanisms – molecular adsorption and cosedimentation in the gel. Enterosgel has expressed sorption of harmful substances, including bacteria and bacterial toxins, antigens, food allergens, medicinal drugs and pathogens, salts of heavy metals, radionuclides, alcohol in the gastrointestinal tract and eliminates them from the body. Enterosgel is also absorbs some of the products of metabolism of the organism, including the excess beat-ruby, urea, cholesterol and lipid complexes, as well as metabolites responsible for the development of endogenous toxicosis. Enterosgel not reduce the absorption of vitamins and microroelementov, the recovery of the disturbed intestinal microflora and does not affect his motor function.

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Enterosgel (PMSPH) is medical device.

According Subsection 41BD(1) of the Therapeutic Goods Act 1989 defines a kind of medical device as:

  • diagnosis, prevention, monitoring, treatment or alleviation of disease;
  • and that does not achieve its principal intended action in or on the human body by pharmacological, immunological or metabolic means, but that may be assisted in its function by such means; or
  • (aa) any instrument, apparatus, appliance, material or other article specified under subsection (2A); or

Enterosgel did not have capacity to ADME (is an abbreviation for absorption, distribution, metabolism and excretion, describes the disposition of a pharmaceutical compound in organism).

PMSPH is not absorbed in the gastrointestinal tract and is excreted unchanged. A robust porous structure of the gel-forming matrix determines absorptive capacity of the mechanism of molecular adsorption and allows mostly to adsorb toxic substances and metabolites (e.g., bilirubin, protein breakdown products).[9]

This is achieved by physical and not pharmacological means. Enterosgel is intended to ‘absorb and remove harmful and toxic substances from the GIT’ because it has potential for adsorbtion in GIT. Thanks to its gelly-like consistency, PMSPH: a) absorbs macromolecular toxic substances by a mechanism of precipitation in the gel (e.g., bacterial toxins);[10] b) exhibits protective properties – elastic gelly-like drug particles form a layer on the mucosal surfaces. This layer protects the mucous membranes from exposure to various damaging factors, while its protective properties are manifested universally – in the intestine and on the mucosal surface of other organs. PMSPH absorbs toxic substances from the gastrointestinal tract as well as toxic substances (xenobiotics) trapped in the gastro-intestinal tract, from the surrounding environment. PMSPH also prevents reabsorption of toxins and metabolites spun into the lumen of the blood as well as transferred to the intestine with bile. PMS PH firmly binds and removes pathogenic bacteria.[11] It should be noted that PMSPH possesses a pronounced ability to absorb lipopolysaccharide molecules. Large lipopolysaccharide molecules coprecipitate in the gel and are excreted.[10]

  • (See below Gun’ko; Turov; Zarko; Goncharuk (2007). “Comparative characterization of polymethylsiloxane hydrogel and silylated fumed silica and silica gel”. Journal of Colloid and Interface Science).

the anti-diarrhoeal category

What is Adsorption?

Adsorption is the phenomenon of accumulation of large number of molecular species at the surface of liquid or solid phase in comparison to the bulk.

How Adsorption occurs?

The process of adsorption arises due to presence of unbalanced or residual forces at the surface of liquid or solid phase. These unbalanced residual forces have tendency to attract and retain the molecular species with which it comes in contact with the surface. Adsorption is essentially a surface phenomenon.

Adsorption is a term which is completely different from Absorption .While absorption means uniform distribution of the substance throughout the bulk, adsorption essentially happens at the surface of the substance. When both Adsorption and Absorption processes take place simultaneously, the process is called sorption.

Adsorption process involves two components Adsorbent and Adsorbate. Adsorbent is the substance on the surface of which adsorption takes place.Adsorbate is the substance which is being adsorbed on the surface of adsorbent. Adsorbate gets adsorbed.

Physical Adsorption or Physisorption

When the force of attraction existing between adsorbate and adsorbent are weak Vanderwaal forces of attraction, the process is called Physical Adsorption or Physisorption. Physical Adsorption takes place with formation of multilayer of adsorbate on adsorbent. It has low enthalpy of adsorption i.e. ΔHadsorption is 20-40KJ/mol.

It takes place at low temperature below boiling point of adsorbate. As the temperature increases in, process of Physisorption decreases.

Physical Adsorption vs. Temperature graph

Physical Adsorption vs. Temperature graph

Physical Adsorption vs. Temperature graph

http://www.chemistrylearning.com/adsorption/

Using Enterosgel

Enterosgel in adults and children as a detoxification agent in:

  • Acute and chronic toxicity of various etiology;
  • Acute poisoning with potent and poisonous substances, including medicinal drugs and alcohol, alkaloids, salts of heavy metals;
  • Acute intestinal infections of any etiology in the complex therapy (toxico-infection, salmonellosis, dysentery, diarrhea syndrome of noninfectious origin, dysbacteriosis);
  • Suppurative-septic diseases accompanied by severe intoxication, in the complex therapy;
  • Food and drug allergy;
  • Hyperbilirubinemia (viral hepatitis) and hyperazotemia (chronic renal insufficiency);
  • For prevention of chronic intoxication in employees of hazardous industries (occupational toxic chemical agents of polytropic action, xenobiotics, incorporated radionuclides, compounds of lead, mercury, arsenic, petroleum products, organic solvents, nitrogen oxides, carbon, fluorides, heavy metal salts).

detoxification agent

The device also absorbs some of the endogenous molecules, including the excess bilirubin, urea, cholesterol and lipid complexes, as well as metabolites responsible for the development of endogenous intoxication. Enterosgel does not reduce the sorption of vitamins and microelements or the recovery of disturbed intestinal microflora and does not affect GIT motion function. (Clinical trials report, Nikolaev et al., 2010; Grigoryev et al., 1988). The product is not absorbed in the gastrointestinal tract, and is excreted unchanged in 12 hours (Slinyakova et Denisova, 1988).

Dosage table

Recommended dosage
Adults one tablespoon (15 g.) 3x daily for a period of 2 to 3 weeks
Children aged 5 to 14 one Teaspoon (10 g.) 3x daily for a period of 2 to 3 weeks
Children under 5 one coffee spoon (5 g.) 3x daily for a period of 2 to 3 weeks

the anti-diarrhoeal category