Every year the range of problems associated with use of sorption technologies in various fields of medicine is expanding. Growing use of sorption processes, in turn, leads to improvement of the properties of older types of sorbents and creation of new sorbents with improved properties and enhanced sorption selectivity toward certain substances. Comparative medico-biological studies of various polymeric materials has shown prospectivity of medical use of organopolysiloxane adsorbents, particularly of polymethylsiloxane (PMS) and its hydrogel, Enterosgel, which consists of a spatially cross-linked porous matrix with a rigid globular structure formed by siloxane chain containing methyl and partially uncondensed hydroxyl groups in silicon atoms. The presence of hydrocarbon radicals provides high affinity of Enterosgel to organic substances (organophilic properties), that is to the toxic metabolites of various nature. In contrast to the known carbon sorbents and highly dispersity silicas, Enterosgel is characterized by apparent selectivity.