SUMMARY: According to recent epidemiological and toxicological data, children living in poor sanitary conditions develop abnormal physical characteristics, such as morphological abnormalities and chronic diseases of the Central Nervous System and the respiratory, cardiovascular, musculoskeletal, endocrine and digestive Systems. Among the substances of industrial origin, an important role is played by metals that accumulate in the tissues and organs. The toxic effects are due to the type of metal, its concentration, the concurrence of other pathological factors and the general health conditions (immune reactivity, hypersensitivity, etc.). The study was conducted on 236 children suffering from mild asthma (experimental Group) living in areas close to metallurgical plants. The composition of the air – concerning the percentage of manganese, chrome, lead and nickel – was found to have values at the upper limits of standard. The control Group, homogeneous for age, gender and residential area, consisted of 41 children. In order to reduce the blood concentrations of the considered toxic metals, 4 enterosorbents were tested and prescribed for 2 consecutive weeks of therapy: Enterosgel ®, Polysorb™, Polyphepan, and activated charcoal. – Enterosgel ® - blood tests. Decrease from baseline: Mn = 12%; Ni = 64 %; Pb = 20 %; Cr = 56 %. – Polysorb™ - blood tests. Decrease from baseline: Mn = 24%; Ni = 65%; Pb = 20 %; Cr = 66%. – Polyphepan - blood tests. Decrease from baseline: Mn = 0 %; Ni = 51 %; Pb = 12%; Cr = 61 %. – Activated charcoal - blood tests. Decrease from baseline: Mn = 0 %; Ni = 69 %; Pb = 10 %; Cr = 44%. Data reveal that the use of Enterosgel ® and Polysorb™ for 2 consecutive weeks allows to obtain a significant reduction – compared to the controls – of the amount of Cr and Ni (56-66%) and Mn and Pb (12-24%) in the blood of asthmatic children living in poor sanitary conditions.