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Osadchaya O.I., Shmatova E.A., Boyarskaya A.M.
Conclusions
1. It has been found that in ALD patients metabolic intoxication is connected with increased activity of lipid peroxidation and accumulation of its products in the peripheral blood. The consequence of these processes is the decrease in the functional activity of neutrophils and their inability to form an adequate response to microbial antigens.
2. Functional failure and high levels of apoptotic-modified neutrophil granulocytes is one of the reasons for the development of auto-aggressive reactions.
3. Application of intestinal adsorbent (enterosorbent) Enterosgel in patients with ALD helps to reduce LPO products - one of the main substrates of metabolic intoxication, which contributes to preservation of the natural functioning of cellular detoxification systems and antimicrobial resistance on subcompensated level and reduces the risk of auto-aggressive reactions.