The colibacillosis are wildly spread all over the world and takes leading positions in etiological structure of acute intestinal infections in children. In our country, due to diagnostic difficulties, rate of registration of colibacillosis is low. The clinical epidemiological characteristics and issues of differentiated diagnostic of the given disease are studied insufficiently. Until nowadays, common approaches to therapy are lacking. The article presents evaluation of therapeutic activity of various methods of start therapy of colibacillosis in children. The clinical efficiency of various classes of antibacterial medications and enterosorbents are presented.