Urology

T. Miksa
published clinical studies conducted with ENTEROSGEL and with other at least partially comparable
medical devices already placed on the European market.
-Translation from the Czech language-

Bioline Products s.r.o.


Gorodetsky, Tebechevsky F Clinical efficacy of Enterosgel in treatment of patients with hepatitis A
Tkachenko E., Avalueva E. The Clinical Efficacy and safety of Enterosgel in the treatment of diarrhoea-dominant irritable bowel syndrome.
Tkachenko E., Avalueva E. The Clinical Efficacy and safety of Enterosgel in the treatment of Helicobacter Pylori – associated chronic gastroduodentis
Astahov V., Gusev V. The Clinical Efficacy and safety of Enterosgel in complex prevention of fetoplacental dysfunction in pregnant women with earlier syphilis
Usenko D., Gorelov A. The Clinical Efficacy of Enterosgel, in treatment of intestinal infections in chidren with atopic dermatitis.
Radchenko V., Seliverstov P. The Clinical Efficacy and safety of Enterosgel in treatment of predialysis Cronic Renal Falure (CRF) patients.
Nakhashova V. The Clinical Efficacy of Enterosgel in treatment of patients with Chronic Pancreatitis
Karlyichuk A., Kulachek F. The Clinical Efficacy of Enterosgel in complex treatment and prophylaxis of post-operative intraperitoneal in complication of acute cholecystitis
Moroz L., Paliy M. Use of enterosorbent Enterosgel in complex therapy of acute viral hepatitis B with concomitant intestinal dysbiosis
Sokolov E., Majev I. Clinical efficacy of Enterosgel in patients with digestive system-relative pathology.
Paliy I., Tchernobroviy V. Clinical efficacy of Enterosgel in complex treatment of intestinal dysbiosis
Yurchenko A., Nikolaev V. Clinical efficacy of Enterosgel in treatment of intoxication and diarrhoea in patients with AIDS during antiretroviral therapy.

Tkach S.M. Effectiveness of Enterosorbent Enterosgel in Combined Anti-Helicobacter Therapy for Patients with Peptic Ulcer Disease
Osadchaya O.I., Boyarskaya A.M. Clinical Effectiveness of Enterosorption in Reduction of Endogenous Intoxication Syndrome in Patients with Nonspecific Ulcerative Colitis
Osadchaya O.I., Shmatova E.A., Boyarskaya A.M. Role of Detoxification Therapy in Maintaining Toxin-binding Capacity of Peripheral Blood Albumin in Patients with Alcoholic Liver Disease
Zaytseva N.V., Aminova A.I., Akatova A.A., Minchenko Ye. Yu. Peculiarities of Eradication Therapy for Chronic H. pylori-associated Gastroduodenitis in Children Living in Ecologically Unfavorable Conditions
Fedorova O.V., Fedulova E.N., Tutina O.A., Korkotashvili L.V. Endogenous Intoxication in Inflammatory Bowel Disease in Children: Substantiation of Detoxification Therapy Using Enterosorption Method
Boyarskaya A.M., Osadchaya O.I., Zhernov A.A., Kovalenko O.N.Use of Enterosorbent Enterosgel in Combination Treatment of Intestinal Dysbiosis in Children with Burn Disease
Enterosgel® in Gastroenterology: Posology and Method of Administration
Dosage and Administration of Enterosgel® for the Treatment of Acute Diarrhea

Nagornaya N.V., Dubovaya A.V. The Detoxifying Potential and Clinical Effectiveness of the Enterosorbent Enterosgel in the Combination Therapy of Various Diseases in Children and Adults
Shamov B.A., Malanicheva T.G. Correction of Systemic Endotoxemia in Children with Atopic Dermatitis
Melnykov O.F., Zabrodska L.V., Tymchenko M.D., Sydorenko T.V., Naumova O.A. A Clinical and Immuno-Allergological Study of the Efficacy of Enterosgel in Food Allergy
Malanicheva T.G., Khaertdinova L.A. Enterosorption in the Treatment of Pediatric Atopic Dermatitis Complicated by Fungal Infection
Baranov A.A, Geppe N.A, Karpushkina A.V. The Efficacy of Enterosgel in the Treatment of Children with Bronchial Asthma and Atopic Dermatitis
J. Bystron. Application of Enterosorption Method with Organosilicon Enterosorbent Enterosgel in the Integrated Treatment of Allergic Diseases
Zaytseva N.V, Aminova A.I., Ustinova O.Yu., Akatova A.A., Luzhetskiy K.P. Asthma Prevention in Children with Recurrent Wheezing Bronchitis Who Have Elevated Levels of Heavy Metals and Aldehydes in the Body
Basieva O.Z., Basiev Z.G. Enterosgel in the Combination Treatment of Atopic Bronchial Asthma
Chorna O.O, Binda T.P. On the Issue of the Treatment of Children with Allergic Diseases
Enterosgel® in Allergology and Dermatology: Posology and Method of Administration

SUMMARY
Report parameters: the report is outlined on 34 pages, contains 6 tables, 1 figure, 1 appendix and 17 literary sources.
List of key words: chronic renal diseases, sorbent, Enterosgel, dialysis.
In the following research feasibility of sorbent Enterosgel® has been studied in predialysis patients with CRF. The work presented has scientifically proven that use of Enterosgel® is effective and safe.

Nikolaev V.G.

Conclusion
It has been established that the incidence of renal diseases in children in the regions of cement industry is very high, especially regarding dysmetabolic nephropathy, unlike the control region, which shows the significant role of environmental factors in the development of renal damage. The conducted studies of Kudin M.V. (2012) [12] have shown that in children and adults living in the area and having no renal diseases cadmium - toxic element, hazard class 1 - accumulates in kidney tissue, which justifies the use of enterosorbent Enterosgel in persons living in the region as a prophylactic purpose.
Enterosgel not only prevents accumulation of toxic substances into the body by their intestinal adsorption, but also contributes to the removal of heavy metals from the urinary system. Inclusion of Enterosgel in the therapy of children with renal diseases living in the region of cement industry leads to the increased urinary excretion of cadmium, chromium, antimony, and arsenic and improvement of urinary symptoms and, above all, reduction of proteinuria, reflecting improved reabsorption function of the epithelium of proximal tubules.
No undesirable effects have been registered in children receiving Enterosgel.

In the recent decades, a steady increase in the number of patients with end-stage chronical kidney disease (CKD) has been observed all over the world. This makes the problem of CKD treatment one of the central in modern nephrology. Considerable progress of renal replacement therapy (RRT), scientific and technical achievements in the field of hemodialysis, widespread introduction of clinic peritoneal dialysis and kidney transplantation have created real conditions for the successful solution of this problem. Bad life prognosis and the inevitable disablement have gone, as well as necessity of absolute avoidance from active social and professional activity [7,11]. At the same time it has become clear that it is important not only to extend life, but also to ensure its high quality.
Conclusions
Method of intestinal adsorption (enterosorption) can be used as a means of CEA elimination. Monotherapy with Enterosgel, the intestinal adsorbent of new generation, reduces the average LPS concentration in the general circulation by 56% and is capable to eliminate CEA in every fourth patient with chronic inflammatory diseases.

Novel intestinal and topical adsorbent drugs with detoxifying effect (studies were conducted in 1980-1990 by order of Main Military Clinical Hospital of the Ministry of Defense of Ukraine) were widely evaluated in military medical facilities. The Military Hospital of Kyiv (nowadays the Main Military Clinical Hospital of the Ministry of Defense of Ukraine) participated in the medical and biological evaluation of novel drugs from the beginning of their development (V.N. Fadeev, F.G. Novikov, N.P. Bezlyuda).

Prevalence of urinary system diseases in Ukraine is 37 per 1000 children and tends towards constant growth. Among the urinary tract infections pyelonephritis (PN) is the most serious problem, which occupies a leading place among nephrology pathologies of childhood [3, 4]. In the recent years, an increase of recurrent and latent disease types is often accompanied by development of intoxication syndrome, probably caused by agents of toxin production, as well as by response of the body, with the development of endotoxemia, metabolic and immune distress.

55 patients with acute pyelonephritis were studied. Of these, 28 patients underwent standard conservative therapy and for 27 patients the standard therapy was paired with sorption therapy using polymethylsiloxane polyhydrate (Enterosgel). As a result, an expressed detoxifying, bactericidal action by Enterosgel was recorded, with use in patients with pyelonephritis against a background of associated diabetes leading to a reduction in blood glucose levels. The use of Enterosgel during comprehensive treatment of acute pyelonephritis allowed a reduction in the severity of illness and number of complications, and to shorten the duration of treatment.
Keywords: acute pyelonephritis (acute bacterial purulent inflammation of the kidneys), enterosorption, Enterosgel, microcirculation.
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