Uses in toxicology
One of the most familiar and well-known approach to treat poisoning at home (food-poisoning or alcohol intoxication) is using enterosorbents. Enterosgel® is a safe and gentle agent with high detoxification properties. Its silicon-organic “sponge-like” structure selectively collects molecules of harmful substances from the gastric tract, actively binds them and naturally releases from the body without damaging the colon tissue.
That helps to reduce the pressure on the gut barrier and assist in restoring epithelium and mucous membrane [1g]*. Enterosgel® is effective in cleansing lymphatic system, as it actively absorbs toxins and prevents toxemia and endotoxicosis. The general detoxification effect of Enterosgelas enterosorbent implies binding molecules of harmful substances in the gastric tract and bringing structural and functional liver units back to norm via improvement of the regional lymph.
Liver recovery timeframe depends on the state of microanatomical organization of hepatic lymph nodes. Enterosgel® improves the activity of parenchymal cells that promote lymphatic drainage, regress hepatic fibrosis and fasten recovery of the liver.
THE ANTIPYRINE TEST
PATIENTS WITH CHRONIC INTOXICATIONS
Enterosgel® treatment is an effective support for the immune system of the patients suffering from chronic intoxication by the complex of toxic substances. That includes saturnism, chronic mercury poisoning, arsenic hydride poisoning or aromatic solvent intoxications (such as benzol and its homologues xylol or toluene).
When following the traditional medical treatment, Enterosgel® helps activate liver monooxygenase (reduced antipyrine half- life as judged by antipyrine elimination test), reduces membrane toxic products of lipid peroxidation (PLP) (alone dialdehyde or dienic conjugates) and improves antioxidant protection.
The cleansing function of the liver is analysed via antipyrine elimination test. It shows the hydroxylase activity in liver microsomes [2f ]. Patients in critical health condition showed antipyrine half-life (T1/2 h) 18.3 ± 1.4 h averagely, or of 24.0 h at its peak. By the end of the therapy the antipyrine half-life level dropped down to 12.0 ± 0.8 h (p < 0.05). Figure 2 represents the antipyrine screening result along with treatment dynamics schedule.
Within the reference group there was no sufficient change of antipyrine half-life observed (15.8 ± 0.99 and 12.8 ± 1.22 prior and after treatment, respectively, > 0.05). The treatment course brought positive results in strengthening cell wall structure. That was proved by clinical tests on correlation among the PLP and antioxidant protection parameters.
Restoration by Enterosgel® of the detoxification function of serum albumin
The detoxification function of serum albumin is an important factor when it comes to preventing endogenous intoxication and further complications. Enterosgel® assists in maintaining its level on the optimum even if the current volume in blood is below the norm.
Enterosgel® -treated patients showed positive dynamics (i.e., 1.62-times higher, P < 0.05) of toxin-binding activity of albumin comparing to baseline value. The mentioned results prove medical effectiveness of Enterosgel® detoxification in restoring of the normal function of the body’s natural protection systems in patients with alcoholic liver disease [3f].
Maintaining of the albumin toxin-binding ability in patients with alcoholic liver disease
ug of dye / mg of protein x 1000