Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus, 2016
S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, V. V. Klimontov, L. N. Rachkovskaya, V. I. Konenkov, and E. L. Zavyalov
Non-alcoholic fatty liver disease is one of the most common complications of obesity and type 2 diabetes mellitus (DM2). The structural trace of metabolic changes in the liver during the development of obesity and DM2 is largely determined by the status of sinusoidal cells involved in the formation of the blood — lymph barrier, including epithelial, Kupffer, Ito, and Pit cells . Endothelial cells of hepatic sinusoids express the lymphatic vessel endothelial hyaluronan receptor marker LYVE-1 . The expression of LYVE-1 in the liver in DM2 and the relationship between LYVE-1 expression and structural and functional changes in the hepatic vessels are not been studied.