Method of intestinal adsorption (enterosorption) can be used as a means of CEA elimination. Monotherapy with Enterosgel, the intestinal adsorbent of new generation, reduces the average LPS concentration in the general circulation by 56% and is capable to eliminate CEA in every fourth patient with chronic inflammatory diseases.
ON ESTABLISHMENT OF LARGE-SCALE PRODUCTION AND HEALTHCARE IMPLEMENTATION OF NOVEL HIGHLY EFFECTIVE POLYORGANOSILOXANE-BASED ADSORBENT DRUGS WITH DETOXIFYING EFFECT, 1994
Bezlyuda N.P., Baranyuk A.P.
Novel intestinal and topical adsorbent drugs with detoxifying effect (studies were conducted in 1980-1990 by order of Main Military Clinical Hospital of the Ministry of Defense of Ukraine) were widely evaluated in military medical facilities. The Military Hospital of Kyiv (nowadays the Main Military Clinical Hospital of the Ministry of Defense of Ukraine) participated in the medical and biological evaluation of novel drugs from the beginning of their development (V.N. Fadeev, F.G. Novikov, N.P. Bezlyuda).
Prevalence of urinary system diseases in Ukraine is 37 per 1000 children and tends towards constant growth. Among the urinary tract infections pyelonephritis (PN) is the most serious problem, which occupies a leading place among nephrology pathologies of childhood [3, 4]. In the recent years, an increase of recurrent and latent disease types is often accompanied by development of intoxication syndrome, probably caused by agents of toxin production, as well as by response of the body, with the development of endotoxemia, metabolic and immune distress.
55 patients with acute pyelonephritis were studied. Of these, 28 patients underwent standard conservative therapy and for 27 patients the standard therapy was paired with sorption therapy using polymethylsiloxane polyhydrate (Enterosgel). As a result, an expressed detoxifying, bactericidal action by Enterosgel was recorded, with use in patients with pyelonephritis against a background of associated diabetes leading to a reduction in blood glucose levels. The use of Enterosgel during comprehensive treatment of acute pyelonephritis allowed a reduction in the severity of illness and number of complications, and to shorten the duration of treatment.
Keywords: acute pyelonephritis (acute bacterial purulent inflammation of the kidneys), enterosorption, Enterosgel, microcirculation.