Ischenko I.Yu., Michurina S.V.

Combined action of carbon tetrachloride and ethanol causes a mixed pattern of pathologic changes in liver. The changes in the regional lymph nodes are due to the overall effect of immunosuppressive action of carbon tetrachloride and immunostimulating influence of ethanol. At the end of recovery period, there was an increase in the functional activity and intensity of recovery processes in the parenchymatous cells of liver. The state of capillary-connective tissue compartment remains strained. Paracortex suppression, stimulation of B-dependent regions and drainage function evidence the strained state of hepatic lymph nodes. The use of the sorbent “Enterosgel” in the recovery period has a corrective effect on the lymph nodes, which favors the fastest recovery of liver. However, the regression of fibrous process in the tissue liver microregion was observed only in the part of experimental animals, which evidences the necessity for continuation of this study.

Key words: hepatitis, lymph nodes, sorbent 

Bezlyuda N.P., Baranyuk A.P.

Novel intestinal and topical adsorbent drugs with detoxifying effect (studies were conducted in 1980-1990 by order of Main Military Clinical Hospital of the Ministry of Defense of Ukraine) were widely evaluated in military medical facilities. The Military Hospital of Kyiv (nowadays the Main Military Clinical Hospital of the Ministry of Defense of Ukraine) participated in the medical and biological evaluation of novel drugs from the beginning of their development (V.N. Fadeev, F.G. Novikov, N.P. Bezlyuda).